ChiroSil® Chiral Columns

The ChiroSil phase is prepared by a covalent trifunctional bonding of (+) or (-)-(18-Crown-6)-tetracarboxylic acid as the chiral selector. This phase, which is available in analytical as well as preparative columns, is an excellent choice for the separation of amino acids and compounds containing primary amines. This chiral stationary phase is highly durable, has universal solvent compatibility, and has the ability to invert elution order of enantiomers by switching columns. In the case of amino acids, most L-enantiomers elute first on the ChiroSil RCA(+) and D-enantiomers elute first on the ChiroSil SCA(-) column.

In general, the separation factors and resolution factors for analytes on ChiroSil are greater than on ChiroSil ME, while capacity factors on ChiroSil ME are greater than on ChiroSil.