IAM Columns for Drug Discovery

Accelerate Drug Discovery using IAM Chromatography

• Rapidly screen drug/phospholipid interactions
• Identify suitable compounds early in the process
• Identify and eliminate compounds with low permeability
• Predict in vivo compound behavior, reducing need for animal studies

Immobilized Artificial Membrane (IAM) technology is an innovative approach to determining drug membrane permeability using a chromatographic column surface that emulates the lipid environment of the cell membrane. As phospholipids are major components of tissues and cells, drug interaction with phospholipids is an important contributor to distribution. IAM chromatography can be used to quickly measure drug/phospholipid interactions via retention times. Regis Technologies IAM Columns are high quality, long lasting HPLC columns providing reliable measurements across a wide range of drug molecules.